A German group recently evaluated the use of antidepressants for
fibromyalgia syndrome (FMS), a chronic pain disorder affecting
multiple points of tenderness. They performed a meta-analysis of
randomized controlled trials published through August 2008. The
studies included randomized placebo-controlled trials involving
tricyclic/tetracyclic antidepressants (TCAs), selective serotonin
reuptake inhibitors (SSRIs), combined serotonin and noradrenaline
reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs).

The study noted a strong association between the use of antidepressants and reduction in pain, fatigue, depression, and sleep disturbances. There was also an improved health-related quality of life. The effects were most notable with TCAs, less with MAOIs, and least with SSRIs or SNRIs.

Source: Hauser W, Bernardy K, Uceyler N, Sommer C. Treatment of fibromyalgia syndrome with antidepressants. JAMA 2009;301:198-209.