The “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Articles

• Telaprevir leads to 75% cure rate in hepatitis C virus (HCV) infected individuals, as shown in late-stage Phase III drug trial. This is a significant improvement over the 40-50% cure rate of the current HCV therapies: interferon and ribavirin. The side effect profile of telaprevir is also much more tolerable than with interferon and ribavirin. If approved by the FDA, telaprevir may also lead to a multi-billion dollar boon for its developer, Vertex Pharmaceuticals. (Reuters)

• Researchers at Ulm University in Germany discovered that children who ate three or more hamburgers a week had a 40% greater risk of developing asthma than those who ate less hamburgers. The group hypothesizes that saturated fats promote asthma by causing inflammation in the airways. This does not apply to all fats, such as omega-3, which may instead have a protective effect. (WebMD)

Technical Articles

• Bilateral necrosis of earlobes and cheeks may be another complication of cocaine. There has been an increasing percentage of cocaine cut with the antihelmintic agent levimasole. Levimasole is an immunomodulating agent that has neutropenia and vasculitis as adverse effects. Physicians from the University of Rochester report two cases of cocaine abusers who developed these yet unknown consequences of cocaine use. (Ann Intern Med)

• Inactive hepatitis B still carries risk for hepatocellular carcinoma and liver-related death. The REVEAL-HBV (Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer in HBV) Study Group found that the annual incidence rates of hepatocellular carcinoma and liver-related death was higher in inactive HBV carriers when compared to uninfected controls. (Gastroenterology)

The “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Articles

• Telaprevir leads to 75% cure rate in hepatitis C virus (HCV) infected individuals, as shown in late-stage Phase III drug trial. This is a significant improvement over the 40-50% cure rate of the current HCV therapies: interferon and ribavirin. The side effect profile of telaprevir is also much more tolerable than with interferon and ribavirin. If approved by the FDA, telaprevir may also lead to a multi-billion dollar boon for its developer, Vertex Pharmaceuticals. (Reuters)

• Researchers at Ulm University in Germany discovered that children who ate three or more hamburgers a week had a 40% greater risk of developing asthma than those who ate less hamburgers. The group hypothesizes that saturated fats promote asthma by causing inflammation in the airways. This does not apply to all fats, such as omega-3, which may instead have a protective effect. (WebMD)

Technical Articles

• Bilateral necrosis of earlobes and cheeks may be another complication of cocaine. There has been an increasing percentage of cocaine cut with the antihelmintic agent levimasole. Levimasole is an immunomodulating agent that has neutropenia and vasculitis as adverse effects. Physicians from the University of Rochester report two cases of cocaine abusers who developed these yet unknown consequences of cocaine use. (Ann Intern Med)

• Inactive hepatitis B still carries risk for hepatocellular carcinoma and liver-related death. The REVEAL-HBV (Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer in HBV) Study Group found that the annual incidence rates of hepatocellular carcinoma and liver-related death was higher in inactive HBV carriers when compared to uninfected controls. (Gastroenterology)

The “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Interest Articles

• Caffeine may lower Alzheimer’s risk … in mice. More studies are however necessary to evaluate whether these findings translate to humans. The news report also poses the question of how many cups one would need to drink in a day (CBS News)

• The first ever 16-patient “domino donor” kidney transplant takes place between June 15 and July 6, 2009. The kidney paired donation (KPD) system involves multiple incompatible donors and recipients, and matching them in a way to accommodate all participants. This system maximizes the chances of being able to donate and receive a kidney transplant (Johns Hopkins Medicine)

• Obesity is linked to the behavior of same-sex their parents and not due to genetics. That is, obese mothers were more likely to have obese daughters. Sons take after their fathers. This study was performed on 226 families by researchers at the Peninsula Medical School. (BBC)

• Heavy drinking is associated with an increased of developing prostate cancer, according to scientists at the University of California, San Francisco (Reuters)

Technical Articles

• Withdrawal of proton-pump inhibitors (PPI) after at least 8 weeks on therapy can result in rebound acid hypersecretion (RAHS) (Gastroenterology)

• [FAMOUS trial] Famotidine is effective in preventing gastric and duodenal ulcers, and erosive esophagitis in patients on chronic low-dose aspirin (Lancet)

• NIH publishes their final guidelines on human stem cell research (NIH)

The FDA (Food and Drug Administration) recently released a public health advisory on Chantix (varenicline), a smoking cessation drug manufactured by Pfizer. This follows an earlier investigation last year on reported behavioral changes associated with use of the drug. The presence of neurologic or psychiatric effects is not completely surprising, considering that Chantix interferes with the brain’s dopamine system. The dysregulation of dopamine has already been implicated in some neuropsychiatric disorders, such as Parkinson’s disease and schizophrenia. Although the drug does not necessarily need to be withdrawn from the market, the FDA cautions both patients and health care providers to be vigilant about past psychiatric conditions and noted mood/behavior changes while on the drug. The FDA adds that use of the drug may interfere with the ability to drive.

Given that lung cancer and heart disease remain among the top killers in the United States, smoking cessation is a key strategy in preventive health. It is hard enough for a smoker to quit. Fortunately there are still several other pharmacologic and non-pharmacologic tools to aid in smoking cessation, including nicotine patches, Wellbutrin (bupropion), and a great coach-physician.