Brown Rice, White Rice: Risk for Diabetes?

white riceThe marketing labels “organic”, “all natural”, and “whole grain” typically bear a positive connotation with broad appeal to health-conscious consumers. Do these foods truly have any health benefits? While “organic” and “all natural” properties of food may have unclear effects, there is mounting evidence that “whole grains” do. Harvard researchers recently compared whole-grain brown rice with refined white rice and evaluated their relative risks for developing type 2 diabetes.

The study analyzed prospective data from 39,765 men and 15,7463 women who participated in 3 separate cohort studies: the Health Professionals Follow-up Study (HPFS) and the Nurses’ Health Study (NHS) I and II. Relevant to this research study, the individual cohort studies had required periodic completion of questionnaires about lifestyle practices and occurrences of chronic diseases.

Individuals who did not complete over 50% of the food items on the food frequency questionnaire (FFQ) were excluded from this study’s analysis. In addition, the researchers excluded those with a pre-existing diagnosis of diabetes, cardiovascular disease, and cancer.

Adjusting for age alone, consumption of >4 servings/week of white rice was associated with a greater risk of developing type 2 diabetes, relative to those who eat <1 serving/month. There was a smaller but similar trend after adjusting for other potential confounders, such as ethnicity, body mass index, smoking status, alcohol intake, multivitamin use, physical activity, and family history of diabetes.

In contrast, consumption of >1 serving/week of brown rice was associated with a lower relative risk of type 2 diabetes, compared to those who eat <1 serving/month. When replacing 50 g/day of white rice with brown rice, there was a 16% decreased risk of diabetes. This risk was 36% lower when white rice was instead substituted with whole grains.

The authors hypothesize that the refinery process that converts brown rice to white rice leads to loss of some protective effects of bran, fiber, vitamins, minerals, lignans, phytoestrogens, and phytic acid.

The findings of this study reinforce that “substitution of whole grains, including brown rice, for white rice may lower risk of type 2 diabetes.” While physicians may counsel their diabetic patients to practice strict carbohydrate control, pre-diabetics should also consider the nutritional impact of their food choices. I will however admit that it is much easier said than done. My acquired taste for white rice is much stronger than for brown rice, and I fear my taste buds may revolt if I were to someday defect to the brown side.

  • Source
  • Sun Q, Spiegelman D, van Dam RM, Holmes MD, Malik VS, Willett WC, Hu FB. White rice, brown rice, and risk of type 2 diabetes in US men and women. Arch Intern Med 2010;170:961-9.
New & Interesting (26 April 2010)

interesting-news-iconThe “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Articles

  • The recommended daily intake of salt is 2000 mg, but the average amount ingested by Americans is over twice that amount. Sometimes we may not be aware of how much salt there is in processed food. This infographic reveals how much salt is contained in different types of food. (Next Generation Food)
  • Dr. Hank Chien, a New York-based plastic surgeon, set the world record in the classic arcade game Donkey Kong with 1,061,700 points in 2 hours and 35 minutes. (American Medical News)

Technical Articles

  • Use of cotrimoxazole (trimethoprim-sulfamethoxazole) and warfarin has been associated with a nearly four-fold increased risk of upper GI tract hemorrhage. (Arch Intern Med)
  • Green tea extracts decreased glucose, triglyceride, and insulin levels in animal models of insulin resistance. Oxidative stress was also reduced, as suggested by lower plasma lipid peroxidation, sulfhydryl (SH) group oxidation, and DNA oxidative damage. (J Am Coll Nutr)
New & Interesting (1 March 2010)

interesting-news-iconThe “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Articles

  • The Sun Herald reports on how cardiologists in Mississippi have been using the iPhone to diagnose patients more quickly through more rapid access to EKGs and other medical information (Sun Herald)
  • The presence of an infection at the time of gluten introduction in childhood is not a major risk factor for celiac disease (Pediatrics)

Technical Articles

  • Updated 2009 guidelines on the diagnosis, prevention, and treatment of catheter-associated urinary tract infections. This was published by the Infectious Diseases Society of America (IDSA). (Clin Infect Dis)
  • A meta-analysis of randomized statin trials revealed a 9% increased risk of diabetes with statin use. The study authors nevertheless add that “the risk is low both in absolute terms and when compared with the reduction in coronary events. Clinical practice in patients with moderate or high cardiovascular risk or existing cardiovascular disease should not change.” (Lancet)
  • Successful development of human liver chimeric mouse model for the study of HBV and HCV infections (J Clin Invest)
  • Eradication of H pylori may help treat gastric low-grade, B-cell, mucosa-associated lymphoid tissue (MALT) lymphoma (Clin Gastroenterol Hepatol)
Low-carbohydrate Versus Low-fat Diet

breadLow-carbohydrate diets were initially popularized by the late Dr. Robert Atkins, who published the fundamentals of this diet in his book Dr. Atkins’ New Diet Revolution. He also founded Atkins Nutritional to commercialize and further evangelize the low-carbohydrate diet. Following Dr. Atkins’s death, however, the popularity of the diet subsided and his company filed for Chapter 11 bankruptcy in 2005.

Despite its controversial nature, the low-carbohydrate diet may still have health benefits. A group at the Center for Health Services Research in Primary Care, Department of Veterans Affairs Medical Center (Durham, North Carolina), recently published their findings in the Archives of Internal Medicine, where they compared the low-carbohydrate, ketogenic diet (LCKD) with a low-fat diet (combined with the weight-loss medication orlistat) regarding their effects on several health parameters: weight loss, blood pressure, cholesterol levels, and glycemic parameters.
Read more … »

New & Interesting (12 August 2009)

interesting-news-iconThe “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Articles

  • Brown fat as a future strategy for weight loss? (NY Times)
  • Blue food dye improves recovery from spinal cord injury in mice (U Rochester)
  • Americans spent $34 billion on alternative medicine in 2007 (ABC)
  • Scientists decode HIV genome (US News)

Technical Articles

  • The FDA initially investigated the association of TNF (tumor necrosis factor) inhibitors with lymphoma or other cancers in children in June 2008, after receiving approximately 30 reports of cancer in children and young adults on the medication. On August 4, 2009, they released their findings of an increased risk of lymphoma, leukemia, and other cancers in children and adolescents who take the TNF inhibitors. They are now requiring a Black Box Warning for these drugs, such as Remicade, Enbrel, Humira, Cimzia, and Simponi. (FDA)