The “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Articles

• Telaprevir leads to 75% cure rate in hepatitis C virus (HCV) infected individuals, as shown in late-stage Phase III drug trial. This is a significant improvement over the 40-50% cure rate of the current HCV therapies: interferon and ribavirin. The side effect profile of telaprevir is also much more tolerable than with interferon and ribavirin. If approved by the FDA, telaprevir may also lead to a multi-billion dollar boon for its developer, Vertex Pharmaceuticals. (Reuters)

• Researchers at Ulm University in Germany discovered that children who ate three or more hamburgers a week had a 40% greater risk of developing asthma than those who ate less hamburgers. The group hypothesizes that saturated fats promote asthma by causing inflammation in the airways. This does not apply to all fats, such as omega-3, which may instead have a protective effect. (WebMD)

Technical Articles

• Bilateral necrosis of earlobes and cheeks may be another complication of cocaine. There has been an increasing percentage of cocaine cut with the antihelmintic agent levimasole. Levimasole is an immunomodulating agent that has neutropenia and vasculitis as adverse effects. Physicians from the University of Rochester report two cases of cocaine abusers who developed these yet unknown consequences of cocaine use. (Ann Intern Med)

• Inactive hepatitis B still carries risk for hepatocellular carcinoma and liver-related death. The REVEAL-HBV (Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer in HBV) Study Group found that the annual incidence rates of hepatocellular carcinoma and liver-related death was higher in inactive HBV carriers when compared to uninfected controls. (Gastroenterology)

The “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Articles

• The recommended daily intake of salt is 2000 mg, but the average amount ingested by Americans is over twice that amount. Sometimes we may not be aware of how much salt there is in processed food. This infographic reveals how much salt is contained in different types of food. (Next Generation Food)

• Dr. Hank Chien, a New York-based plastic surgeon, set the world record in the classic arcade game Donkey Kong with 1,061,700 points in 2 hours and 35 minutes. (American Medical News)

Technical Articles

• Use of cotrimoxazole (trimethoprim-sulfamethoxazole) and warfarin has been associated with a nearly four-fold increased risk of upper GI tract hemorrhage. (Arch Intern Med)

• Green tea extracts decreased glucose, triglyceride, and insulin levels in animal models of insulin resistance. Oxidative stress was also reduced, as suggested by lower plasma lipid peroxidation, sulfhydryl (SH) group oxidation, and DNA oxidative damage. (J Am Coll Nutr)

The “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Articles

• The Sun Herald reports on how cardiologists in Mississippi have been using the iPhone to diagnose patients more quickly through more rapid access to EKGs and other medical information (Sun Herald)

• The presence of an infection at the time of gluten introduction in childhood is not a major risk factor for celiac disease (Pediatrics)

Technical Articles

• Updated 2009 guidelines on the diagnosis, prevention, and treatment of catheter-associated urinary tract infections. This was published by the Infectious Diseases Society of America (IDSA). (Clin Infect Dis)

• A meta-analysis of randomized statin trials revealed a 9% increased risk of diabetes with statin use. The study authors nevertheless add that “the risk is low both in absolute terms and when compared with the reduction in coronary events. Clinical practice in patients with moderate or high cardiovascular risk or existing cardiovascular disease should not change.” (Lancet)

• Successful development of human liver chimeric mouse model for the study of HBV and HCV infections (J Clin Invest)

• Eradication of H pylori may help treat gastric low-grade, B-cell, mucosa-associated lymphoid tissue (MALT) lymphoma (Clin Gastroenterol Hepatol)

The “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Articles

• The Lancet, a prominent British medical journal, formally retracted the original article that associated the MMR (measles, mumps, rubella) vaccine with autism. The article, authored by Dr. Andrew Wakefield, had caused mass hysteria among parents who refused to have their children vaccinated, leading to a rise in the incidence of measles. Follow-up studies have however debunked the original hypothesis, and retrospective review by the medical journal reveals “that several elements of the 1998 paper by Wakefield … are incorrect”. (Washington Post)

• Automated telephone outreach does not increase colorectal screening rates (Arch Intern Med)

Technical Articles

• PRORATA trial: Use of the biomarker procalcitonin to guide treatment of suspected bacterial infections reduced duration of antibiotic use in the intensive care unit (ICU). (Lancet)

• Decreased tissue levels of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hydroxylase (TPH2) are associated with sudden infant death syndrome (SIDS). Presumably, abnormalities in autonomic function interferes with the the infant’s ability to detect and/or respond to high CO₂ levels, leading to hypoxic death. (JAMA)

The “New & Interesting” series is a biweekly compilation of select research findings, news articles, and random tidbits in bullet-point format. The entries are highly abbreviated, but provide links to the original articles or abstracts if you desire to read further.

General Articles

• Antibiotics can be purchased online without the need for a prescription. The danger of making this freely available is the indiscriminant use of antibiotics to treat infections inappropriately. Moreover, this leads to the progressive selection of organisms resistant to current drug therapies. (Ann Fam Med)

• AIDS vaccine reduces rate of new infections by 31%. Although modest, this is the first time a vaccine has shown any efficacy against the spread of HIV since the discovery of the virus 26 years ago. (LA Times)

• Nocturnal gastroesophageal reflux disrupts sleep and causes insomnia (Clin Gastroenterol Hepatol)

• Do mobile phones cause brain tumors? A meta-analysis performed by a team led by Dr. Seung-Kwon Myung of South Korea’s National Cancer Center found a mild increase in risk of benign brain tumors in people who have used cell phone for over a decade. Larger studies are still needed to answer this question. (Reuters)

Technical Articles

• Risk of hyperkalemia is small with use of ACE inhibitors in nondiabetic patients with hypertensive CKD (chronic kidney disease) (Arch Intern Med)

• Glucocorticoid use associated with increased risk of atrial fibrillation or flutter (Arch Intern Med)